In this academic article, the authors explore two contemporary movements associated with the literature and art of the Amazon region: Amazofuturism and Indigenous futurism. Amazofuturism is understood as a subgenre with ties to cyberpunk and/or solarpunk, in which the future of the Amazon region is portrayed in a broadly optimistic light. Indigenous futurism refers primarily to speculative artwork and writing by Indigenous people, which expresses Indigenous perspectives and epistemologies, and/or which centres Indigeneous experience. Indigenous futurism opposes reductive, pessimistic, and exoticising discourses about the Amazon region and Indigenous peoples, challenging Western stereotypes and allowing the complexity of Indigenous voices and perspectives to be shared. Together, both these interconnected movements attest to the power of the speculative imagination in social and political resilience and regeneration.